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目的:探讨腹腔镜手术联合GnRHa治疗卵巢子宫内膜异位囊肿的临床疗效。方法:选择2005年1月～2010年12月该院收治的子宫内膜异位囊肿患者120例,按随机数字表法分为观察组和对照组各60例。两组均行腹腔镜手术,对照组术后行常规冲洗,抗感染治疗;观察组在此基础上术后加用GnRHa,3.75 mg/次,每28天肌注1次,疗程3～6个月。观察两组症状缓解率,复发率,合并不孕症患者的妊娠率,月经恢复及不良反应。结果:观察组症状缓解率、复发率及妊娠率分别为88.3%(53/60)、5.0%(3/60)、66.7%(18/27),对照组分别为66.7%(40/60)、20.0%(12/60)、30.8%(8/26),差异均有统计学意义(P<0.05)。结论:腹腔镜手术联合GnRHa治疗卵巢子宫内膜异位囊肿能有效提高症状缓解率和妊娠率,减少复发,值得临床推广应用。
Objective: To investigate the clinical efficacy of laparoscopic surgery combined with GnRHa in the treatment of ovarian endometriosis. Methods: From January 2005 to December 2010, 120 cases of endometriotic cyst admitted to our hospital were divided into observation group and control group according to random number table method, 60 cases each. The patients in the control group underwent laparoscopic surgery and the control group received conventional irrigation and anti-infective therapy. On the basis of this observation, the observation group received GnRHa 3.75 mg / time, intramuscular injection once every 28 days for 3 to 6 month. Two groups were observed the rate of symptom relief, relapse rate, pregnancy rate, menstruation recovery and adverse reactions in patients with infertility. Results: The symptom relief rate, recurrence rate and pregnancy rate were 88.3% (53/60), 5.0% (3/60) and 66.7% (18/27) in the observation group and 66.7% (40/60) in the control group respectively , 20.0% (12/60) and 30.8% (8/26), respectively. The differences were statistically significant (P <0.05). Conclusions: Laparoscopic surgery combined with GnRHa in the treatment of ovarian endometriosis cyst can effectively improve the rate of symptom relief and pregnancy rate and reduce the recurrence, which deserves clinical application.