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目的 探讨胃癌术中腹腔内温热灌洗化疗 (intraperitonealhyperthermicperfusionchemotherapy ,IHPC)加腹膜内注射化疗对胃癌术后腹膜转移和生存期的影响。 方法 将胃癌患者5 8例随机分成A、B两组 ,A组单行手术治疗 ,B组行手术加IHPC及丝裂霉素 活性炭混悬液(MMC CH)腹膜内注射 ,观察两组病人术后的并发症及 1、3年生存率。结果 A组 1年生存率为86 .6 7% ,B组为 85 .71% ,P >0 .0 5。A组 3年生存率为 36 .6 7% ,B组为 5 7.14 % ,P <0 .0 1。两组病人术后 3年生存率之间的差异有显著性 ,但两组病人术后并发症之间的差异无显著性。结论 胃癌手术中辅以IPHP及腹膜内注射化疗对于防治胃癌的腹膜淋巴转移、腹膜复发 ,提高生存率有重要价值。
Objective To investigate the effects of intraperitoneal hyperthermic perfusion chemotherapy (IHPC) and intraperitoneal injection chemotherapy on postoperative peritoneal metastasis and survival of gastric cancer. Methods A total of 58 patients with gastric cancer were randomly divided into A and B groups. Surgical treatment was performed in group A. In group B, peritoneal injection of IHPC and mitomycin C activated carbon (MMC CH) was injected intraperitoneally to observe the two groups of patients. Complications and 1- and 3-year survival rates. Results The 1-year survival rate was 86.67% in group A and 85.71% in group B, P>0.05. The 3-year survival rate was 36.67% in group A and 5.71% in group B, P < 0.01. The difference in postoperative 3-year survival rate between the two groups of patients was significant, but there was no significant difference in postoperative complications between the two groups. Conclusion IPHP combined with intraperitoneal injection of chemotherapy in gastric cancer surgery is of great value in preventing and treating peritoneal lymphatic metastasis, peritoneal recurrence, and survival rate of gastric cancer.