目的:探索伴轻中度抑郁的功能性消化不良(functional dyspepsia,FD)患者血浆和胃黏膜中5-羟色胺(5-hydroxytryptamine,5-HT)与不伴抑郁的FD患者间的差异,为实验室评估FD患者抑郁程度和治疗疗效提供理论依据。方法:门诊FD患者经医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)抑郁评分分为2组,即伴轻中度抑郁的FD试验组30例和不伴抑郁的FD对照组30例,采集2组患者的血液和胃黏膜标本,酶联免疫吸附法(enzyme-linked immunosorbent method,ELISA)法检测血浆及胃黏膜中5-HT的含量。结果:试验组血浆及胃黏膜5-HT含量均较对照组增高,2组差异有统计学意义(P=0.000);抑郁程度评分与血浆5-HT含量成正相关(r=0.921,P=0.000),同时也与胃黏膜5-HT含量成正相关(r=0.954,P=0.000)。结论:FD伴轻中度抑郁时存在神经内分泌的异常,5-HT在其发病过程中起重要作用,其可作为FD患者抑郁程度评估和抗抑郁疗效评估的依据之一。 OBJECTIVE: To explore the differences between 5-hydroxytryptamine (5-HT) and non-depressed FD patients in plasma and gastric mucosa with mild to moderate functional dyspepsia (FD) Room evaluation of FD patients with depression and treatment efficacy to provide a theoretical basis. Methods: The outpatient FD patients were divided into two groups according to the depression score of hospital anxiety and depression scale (HADS), that is, 30 FD patients with mild to moderate depression and 30 FD patients without depression, Blood and gastric mucosa were collected from two groups of patients, and the contents of 5-HT in plasma and gastric mucosa were detected by enzyme-linked immunosorbent assay (ELISA). Results: The contents of 5-HT in plasma and gastric mucosa in experimental group were significantly higher than those in control group (P = 0.000). There was a positive correlation between depression score and plasma 5-HT content (r = 0.921, P = 0.000 ), But also with gastric mucosa 5-HT content was positively correlated (r = 0.954, P = 0.000). Conclusions: Neuroendocrine abnormalities exist in FD patients with mild to moderate depression, and 5-HT plays an important role in the pathogenesis of FD. It may be used as a basis for evaluating depression and antidepressant efficacy in patients with FD.