作者经大量流行病学调查证实,HBV感染和原发性肝细胞癌(PHC)有关。作者在1970年观察到,地中海区患肝硬化合并PHC病人的血清中HBsAg普遍流行,并认识到病毒和肿瘤之间的联系。例如,居民由高HBsAg携带者区/高PHC区迁移到低HBsAg携带者区/低PHC区时,他们仍有同样高的PHC发病率,就像在他们原来的地 A large number of epidemiological investigations confirmed that HBV infection is associated with primary hepatocellular carcinoma (PHC). The authors observed in 1970 that the prevalence of HBsAg in the serum of patients with cirrhosis and PHC in the Mediterranean was widespread and recognized the link between the virus and the tumor. For example, residents who migrate from high HBsAg carriers / high PHCs to low HBsAg carriers / low PHCs have the same high incidence of PHC as they did in their original