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SARS相关冠状病毒引起严重急性呼吸综合征(SARS)。该病毒在患者痰液中含量最高,在咽喉部和血浆中分布较少,在患者粪便中可长时间存活。微尘和飞沫是主要传播途径。合并多种基础疾病的老年SARS患者易于发生老年多器官功能衰竭(MOFE)可能是其高病死率的主要原因。老年SARS患者启动MOFE的主要机制可能为组织细胞缺氧、血液中内毒素水平升高和全身炎症反应水平、老年人器官储备功能降低。
SARS-associated coronavirus causes severe acute respiratory syndrome (SARS). The virus in patients with the highest content of sputum, less in the throat and plasma distribution, in the patient’s stool can survive for a long time. Dust and droplets are the main routes of transmission. Aged patients with multiple organ diseases complicated with multiple underlying diseases prone to multiple organ failure (MOFE) may be the main cause of their high case-fatality rates. The main mechanism of MOFE initiation in elderly patients with SARS may be tissue cells hypoxia, elevated levels of endotoxin in blood and systemic inflammatory response, and lower organ reserve function in the elderly.