目的 通过对496例结肠癌临床病理学特征总结,指导治疗。方法 以常规病理学方法统计分析,并以直接法计算生存率。结果 ①结肠癌男性多发,40岁以上病人发病风险高。②好发部位为升结肠和乙状结肠。③病期晚期病人比例高。④淋巴结转移率为48.38％,其中第4站转移率为10％。⑤远隔脏器转移,邻近器官侵犯比例较高。结论 欲提高结肠癌的5年生存率,应注重早期发现,早期诊断,早期治疗,同时行根治术及扩大根治术及联合脏器切除术。 Objective To summarize the clinicopathological characteristics of 496 cases of colon cancer and guide treatment. Methods Statistical analysis was performed using routine pathology methods and the survival rate was calculated by the direct method. Results 1 Multiple colon cancers occurred in men, and the risk of onset was high in patients over 40 years old. 2 The predilection sites were ascending colon and sigmoid colon. The proportion of patients with advanced stage 3 is high. 4 The rate of lymph node metastasis was 48.38%, of which the metastasis rate at the 4th station was 10%. 5 distant organ transfer, a higher proportion of adjacent organs. Conclusions To improve the 5-year survival rate of colon cancer, early detection, early diagnosis, and early treatment should be emphasized. At the same time, radical surgery, extended radical mastectomy, and combined organ resection should be performed.