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目的探讨组织蛋白酶Ｄ（ＣＤ）与骨肉瘤患者预后的关系。方法应用免疫组化技术检测３４例骨肉瘤组织标本中的ＣＤ表达水平，并结合患者临床病案记录和随访资料进行分析。结果ＣＤ高表达与低表达之间的肿瘤转移人数和２年生存人数差异显著，且ＣＤ低表达患者的平均生存时间较高表达者为长。经Ｋａｐｌａｎ┐Ｍｅｉｅｒ分析，两组间生存率有显著差异。结论ＣＤ高表达的骨肉瘤易发生转移，预后不良，应加强治疗。
Objective To investigate the relationship between cathepsin D (CD) and the prognosis of osteosarcoma patients. Methods Immunohistochemical technique was used to detect the expression of CD in 34 specimens of osteosarcoma, combined with clinical records and follow-up data. Results There was a significant difference in the number of tumor metastasis and 2-year survival between high and low CD expression, and the higher mean survival time for patients with low CD expression was longer. The Kaplan┐Meier analysis showed a significant difference in survival rates between the two groups. Conclusion The high expression of osteosarcoma in CD is easy to metastasize and the prognosis is poor. It should be strengthened.