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一、洗必泰 张中一 洗必泰作为一种常用的消毒防腐剂,因其具有杀菌范围广、效力强、速度快、毒性小和成本低的特点,而逐步作为预防和治疗药用于临床。 (一)治疗急性菌痢 刘德兴等在治疗急性痢疾新药“新痢灵”的研究中,为寻找高效、速效、低毒的急性菌痢治疗药物,以130株痢疾杆菌对15种药物进行药物敏感试验,发现有13种药物产生不同程度的耐药性,唯独洗必泰未发现耐药株。故选用该药与抗菌增效剂等组成复方“新痢灵”片(由洗必泰和TMP组成)。用这种“新痢灵”片治疗菌痢患者977例,治愈936例,治愈率为95.8％,有效率为96.83％,且复发率低,作者还对洗必泰进行急性和多次毒性实验:结果大白鼠LD56大于5000-
First, chlorhexidine Zhang Zhongyi chlorhexidine as a commonly used disinfectant preservative, because of its wide range of sterilization, effective, fast, low toxicity and low cost characteristics, and gradually as a preventive and therapeutic drug used in clinical. (A) the treatment of acute bacillary dysentery Liu Dexing et al in the treatment of acute dysentery drug “new dysentery” study, in order to find efficient, quick, low toxicity acute bacillary dysentery drug to 130 Shigella flexneri 15 drug sensitivity Test, found that 13 kinds of drugs have different degrees of resistance, only chlorhexidine did not find resistant strains. Therefore, the selection of the drug and antibacterial synergist and other components of compound “new dysentery” film (composed of chlorhexidine and TMP). 977 cases of bacillary dysentery were treated with this “new dysentery” tablet, 936 cases were cured, the cure rate was 95.8%, the effective rate was 96.83%, and the recurrence rate was low. The author also conducted acute and multiple toxicity tests on chlorhexidine : Results Rat LD56 greater than 5000-