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在国外,放射性131碘已经被公认为治疗成人及儿童Graves’甲亢的有效、安全、简便的方法。但在我国目前还未能普遍推广,主要原因是该法可引起高发生率的甲状腺机能减退症(甲减)。我国甲亢患者难以承受甲减带来的生理、心理、经济等方面的压力和负担。因此,一些学者对采用131I治疗甲亢,既要提高治愈率,又要尽量减少甲减的发生率进行了研究。他们认为采用131I治疗甲亢发生甲减与年龄、有无突眼、甲亢病程、治疗前抗甲状腺药物的应用、131I的应用剂量、131I治疗次数、甲状腺大小、甲状腺组织对131I的敏感性、131I在体内的有效半减期、自身免疫状况等因素有关。我院认为与发病年龄小,病情较轻、病程较短、甲状腺质量小、质软等因素有关。可见,探讨采用131I治疗甲亢及其引起甲减危险因素,是我国采用放射性131碘治疗甲亢亟待需要解决的课题。
Abroad, radioactive iodine 131 has been recognized as an effective, safe and easy way to treat Graves’ hyperthyroidism in both adults and children. However, it is still not universally available in our country at present, mainly because this law can cause a high incidence of hypothyroidism (hypothyroidism). Hypothyroidism patients in China are hard to withstand the hypothyroidism brought about the physical, psychological, economic and other aspects of the pressure and burden. Therefore, some scholars on the use of 131I treatment of hyperthyroidism, it is necessary to improve the cure rate, but also to minimize the incidence of hypothyroidism were studied. They considered the use of 131I treatment of hyperthyroidism hypothyroidism and age, with or without ophthalmopathy, hyperthyroidism duration, the application of anti-thyroid drugs before treatment, the application dose of 131I, 131I treatment times, thyroid size, 131I sensitivity of thyroid tissue, 131I in Effective half-life in vivo, autoimmune conditions and other factors. Our hospital that with the age of onset, less serious illness, shorter duration, thyroid quality is small, soft and other factors. Visible, to explore the use of 131I treatment of hyperthyroidism and its risk factors for hypothyroidism, is the use of radioactive 131 iodine treatment of hyperthyroidism urgent need to be addressed.