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目的探讨肝硬化患者体内一氧化氮（NO）产生量与临床表现的关系。方法以Rivonal反应法检测血浆NOZ，评估NO产量，同时检测患者肝功、电解质、尿钠，对结果进行统计学分析。结果各组肝硬化患者血浆NO2-含量均高于对照组（分别为P＜0．05和P＜0．01），但与肝功各指标无相关性。高NO2-组平均动脉压、尿钠显著减少（P＜0．01），腹水、功能性肾衰发生率明显增加（P＜0．01和P＜0．05）。结论肝硬化时NO合成增加并可能介导高动力循环，从而引起腹水、浮肿等并发症。
Objective To investigate the relationship between nitric oxide (NO) production and clinical manifestations in patients with cirrhosis. Methods Plasma NOZ was detected by Rivonal reaction method, NO production was assessed, and liver function, electrolytes and natriuresis were measured simultaneously. The results were statistically analyzed. Results The levels of plasma NO2- in cirrhotic patients in each group were higher than those in control group (P <0.05 and P <0.01, respectively), but not correlated with the indexes of liver function. In the high NO2 group, the mean arterial pressure was significantly lower (P <0.01) and the incidence of ascites and functional renal failure was significantly increased (P <0.01 and P <0.05). Conclusions NO synthesis increases in cirrhosis and may mediate hyperdynamic circulation leading to complications such as ascites and edema.