In this work the enhanced molecularly imprinted optosensing material based on graphene oxide-quantum dots( GOQDs) was synthesized for highly selective and sensitive specific recognition of the target protein,bovine serum albumin( BSA).Here,GO was introduced to enhance the efficiency of mass-transfer in recognition of target protein.Molecularly imprinted polymer coated GO-QDs using BSA as template( BMIP-coated GO-QDs)exhibited a fast mass-transfer speed,which could be ascribed to the high volume of efficient surface area and high target recognition efficiency of the synthesized nanoscale device.Under optimal conditions,it was found that the BSA as target protein could remarkably quench the relative fluorescence intensity of BMIPcoated GO-QDs linearly in a concentration-dependent manner that was best described by a Stern-Volmer equation.The KSV( SternVolmer constant) for template BSA was much higher than bovine hemoglobin( BHb) and lysozyme( Lyz),implying a highly selective recognition ability of the BMIP-coated GO-QDs to BSA.This enhanced fluorescent nanoscale device may provide opportunities to develop a system that is efficient and effective and has potential in the design of highly effective fluorescent receptor for recognition of target protein in proteomics studies. In this work the enhanced molecularly imprinted optosensing material based on graphene oxide-quantum dots (GOQDs) was synthesized for highly selective and sensitive specific recognition of the target protein, bovine serum albumin (BSA). Here, GO was introduced to enhance the efficiency of mass-transfer in recognition of target protein. Molecularly imprinted polymer coated GO-QDs using BSA as template (BMIP-coated GO-QDs) exhibited a fast mass-transfer speed, which could be ascribed to the high volume of efficient surface area and high target recognition efficiency of the synthesized nanoscale device. Uniform optimal conditions, it was found that the BSA as target protein could remarkably quench the relative fluorescence intensity of BMIPcoated GO-QDs linearly in a concentration-dependent manner that was best described by a Stern-Volmer equation. The KSV (SternVolmer constant) for template BSA was much higher than bovine hemoglobin (BHb) and lysozyme (Lyz), implying a highly selective recognition a bility of the BMIP-coated GO-QDs to BSA.This enhanced fluorescent nanoscale device may provide opportunities to develop a system that is efficient and effective and has in in design of highly effective fluorescent receptor for recognition of target protein in proteomics studies.