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目的:探讨分析非血液透析慢性肾功能衰竭(CRF)患者肾性营养不良、肾性贫血与血清淀粉样蛋白A(SAA)之间的关系。方法:抽取63例2012.1.1~2013.1.1之间在我院接受治疗的非血液透析慢性肾功能衰竭患者以及31例入院接受健康体检的人群,采用回顾性的方法分析,并根据肾小球的滤过率将其分为三个亚组,每组21人,即甲组、乙组和丙组,并对各组患者的血清SAA水平采用酶联免疫吸附法进行测定,同时还测定各组患者的肾功能、肝功能以及血常规,并将各组数据与正常受检者进行对比。结果:其调查结果显示,非血液透析慢性肾功能衰竭患者与正常受检组相比,其血红蛋白和血清白蛋白的水平要明显的低出许多,而血清SAA的水平要明显高出许多,由此可见,非血液透析慢性肾功能衰竭患者血红蛋白和血清白蛋白的水平与血清SAA的水平呈负相关,差异具有统计学意义(P<0.05)。结论:血清SAA的水平在非血液透析慢性肾功能衰竭患者中呈上升趋势,其原因可能是由于不同机制参与导致的肾性贫血、肾性营养不良。
Objective: To investigate the relationship between renal dystrophy, renal anemia and serum amyloid A (SAA) in patients with chronic hemodialysis without renal failure (CRF). Methods: Sixty-three patients from non-hemodialysis patients with chronic renal failure treated in our hospital from January 2012 to January 2013 were enrolled, and 31 healthy people admitted to hospital were retrospectively analyzed. Of the filtration rate will be divided into three subgroups, 21 in each group, namely Group A, Group B and Group C, and serum SAA levels in each group were measured by enzyme-linked immunosorbent assay, Group of patients with renal function, liver function and blood, and each group of data and normal subjects were compared. Results: The results of the survey showed that the levels of hemoglobin and serum albumin were significantly lower in non-hemodialysis patients with chronic renal failure than those in the normal subjects, whereas serum SAA levels were significantly higher than those in the normal subjects This shows that patients with chronic hemodialysis non-hemodialysis hemoglobin and serum albumin levels and serum SAA levels was negatively correlated, the difference was statistically significant (P <0.05). CONCLUSIONS: Serum SAA levels are increasing in non-hemodialysis patients with chronic renal failure, which may be due to renal anemia and renal malnutrition due to different mechanisms involved.