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诊断治疗药物作为一种新兴的治疗策略,展现出良好的应用前景。基于磁性氧化铁纳米粒的诊断治疗药物利用纳米技术将纳米粒与治疗性药物同时装载于纳米粒上,该纳米系统一般由三部分组成:磁性纳米粒核心、包覆层及功能区域。该系统可以用于影像诊断、实时监测药物输送、进行药效评价,并有望用于个体化医疗。本文介绍了磁性氧化铁纳米粒的合成、表面修饰、功能化及其生物医学应用等,重点介绍了磁性氧化铁纳米粒的表面修饰及功能化,经过表面修饰及功能化后,可制得多模式化、多功能化的诊断治疗药物,并对纳米诊断治疗药物在应用于个体化医疗所面临的挑战进行了初步的分析讨论。
Diagnosis and treatment of drugs as a new treatment strategy, showing a good prospect. Magnetic nanoparticles based on the diagnosis and treatment of drugs using nano-technology nanoparticles and therapeutic drugs simultaneously loaded on the nanoparticles, the nanometer system generally consists of three parts: magnetic nanoparticles core, coating and functional areas. The system can be used for imaging diagnosis, real-time monitoring of drug delivery, efficacy evaluation, and is expected to be used for personalized medicine. In this paper, the synthesis, surface modification, functionalization and biomedical applications of magnetic iron oxide nanoparticles were introduced. The surface modification and functionalization of magnetic iron oxide nanoparticles were mainly introduced. After surface modification and functionalization, Model, multi-functional diagnosis and treatment of drugs, and nanotechnology diagnosis and treatment of drugs in the application of the challenges facing individualized medical conducted a preliminary analysis and discussion.