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目的探讨血浆亚油酸水平与急性缺血性脑卒中发病的关系,为急性缺血性脑卒中的早期预防和诊断提供科学的依据。方法采用以昆山市中医院为基础的1︰1病例对照研究,根据纳入标准选择急性缺血性脑卒中患者,并根据性别;年龄±2岁;收缩压±2 mm Hg选择对照组。收集研究对象人口统计学特征、体格检查和实验室检查等资料。按血浆亚油酸水平的四分位数将其分为4等分位,采用条件Logistic回归模型来分析血浆亚油酸水平与急性缺血性脑卒中发病的关系。结果病例组的血浆亚油酸水平低于对照组。以血浆亚油酸水平<228.77μg/ml为参比组,在调整了总胆固醇、甘油三酯等因素后发现,亚油酸水平在228.77~283.59μg/ml时,发生急性缺血性脑卒中的OR值为0.139(95%CI:0.012~1.639),亚油酸水平在283.59~352.90μg/ml时,发生急性缺血性脑卒中的OR值为0.085(95%CI:0.007~0.973),亚油酸水平在≥352.90μg/ml时,发生急性缺血性脑卒中的OR值为0.021(95%CI:0.001~0.407),且随着血浆亚油酸水平的升高,急性缺血性脑卒中的发病风险逐步降低(趋势性检验P值为0.009)。结论高浓度的血浆亚油酸水平可以降低急性缺血性脑卒中的发病风险,并存在剂量反应关系。
Objective To investigate the relationship between plasma linoleic acid levels and the incidence of acute ischemic stroke and provide a scientific basis for the early prevention and diagnosis of acute ischemic stroke. Methods A 1: 1 case-control study based on Kunshan Hospital of Chinese Medicine was conducted. Patients with acute ischemic stroke were selected according to inclusion criteria and were selected according to sex; age ± 2 years; systolic blood pressure ± 2 mm Hg. Collected demographic characteristics of the study, physical examination and laboratory tests and other information. According to the quartile of plasma linoleic acid level, they were divided into 4 quartiles. Logistic regression model was used to analyze the relationship between plasma linoleic acid level and the incidence of acute ischemic stroke. Results The plasma linoleic acid level of the case group was lower than that of the control group. Taking the plasma linoleic acid level <228.77μg / ml as the reference group, we found that when the level of linoleic acid is 228.77 ~ 283.59μg / ml, acute ischemic stroke occurs after adjusting the total cholesterol, triglyceride and other factors (95% CI: 0.012-1.639), OR of 0.085 (95% CI: 0.007-0.973) for acute ischemic stroke at the level of linoleic acid between 283.59 and 352.90μg / ml, The OR for acute ischemic stroke was 0.021 (95% CI: 0.001-0.407) when linoleic acid level was ≥352.90μg / ml. With the increase of plasma linoleic acid level, the acute ischemic The risk of stroke was gradually reduced (trend test P = 0.009). Conclusion High concentration of plasma linoleic acid can reduce the risk of acute ischemic stroke, and there is a dose-response relationship.