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目的：观察化疗联合薏苡仁提取物治疗脑转移瘤的疗效。方法脑转移瘤患者60例，预计生存期3个月以上，Karnofsky体力状况（KPS）评分≥60分。60例患者随机分为观察组33例和对照组27例。两组患者均先给予甘露醇静脉滴注，继之化疗，原发肿瘤相同的脑转移瘤化疗方案一致（紫杉醇联合顺铂、培美曲塞联合顺铂或吉西他滨联合顺铂）。治疗期间两组不加任何其他辅助中成药物和免疫制剂；仅观察组加用薏苡仁提取物200 m l静脉滴注，每天1次，连续21 d为1个疗程。治疗2个疗程后按实体瘤疗效评价标准及K PS评分评价疗效。结果治疗2个疗程后，观察组有效率和疾病控制率分别为18.2％和48.5％，均高于对照组的14.8％和44.4％，但差异无统计学意义（P＞0．05）；但观察组 KPS 评分改善率高于对照组（69.7％ vs ．44.4％），差异有统计学意义（P＜0．05）。结论化疗的基础上，联合应用薏苡仁提取物治疗脑转移瘤可改善患者的体力活动状况。“,”Objective To observe the efficacy of chemotherapy combined with Coix seed extract in treating brain metastatic tumor .Methods Sixty patients with brain metastatic tumor were treated with mannitol combined with chemotherapy of same regimens (cisplatin combined with paclitaxel , pemetrexed or gemcitabine) ,who were divided into groups of A (treated additionally with intravenous infusion of Coix seed extract 200 ml) and B (without Coix seed extract as the control ) .Coix seed extract was infused daily for 21 days as one therapeutic cycle .The efficiency and KPS score were evaluated two therapeutic cycles after treatment .Results The effectiveness rate and disease control rate of group A were 18.2% and 48.5% ,which were slightly higher than 14.8% and 44.4% of group B(P>0 .05) .But the improvement rate of KPS score was higher in group A than that in group B (69.7% vs .44.4% )(P<0 .05) .Conclusion On the basis of chemotherapy ,combined use of Coix seed extract may improve the physical activity status of the patients with brain metastatic tumor .