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目的 动态研究脑梗死患者组织型纤溶酶原激活物 (t- pA)活性、D -二聚体 (D -D)含量变化 ,探讨其临床意义。方法 检测 4 6例脑梗死患者发病 7天、14天、2 8天及 4 0例健康对照组血浆t- pA活性及D -D水平 ,并进行脑梗死患者临床神经功能缺损程度评分。 结果 与对照组相比 ,脑梗死患者急性期、亚急性期和恢复期血浆t-pA活性显著降低 ,D -D含量显著增加并随着病情改善而有所恢复 ,二者动态变化量愈大 ,病情改善程度愈明显。结论 血浆t -pA降低可能是脑梗死病因之一 ,D -D含量增高是血栓溶解标志 ,动态观察二者变化可作为判断病情及预后指标之一。
Objective To investigate the changes of tissue-type plasminogen activator (t-pA) activity and D-dimer (D-D) in patients with cerebral infarction and to investigate its clinical significance. Methods The plasma levels of t-pA and D-D were measured at 7 days, 14 days, 28 days and 40 healthy controls in 46 patients with cerebral infarction. The scores of clinical neurological deficits were evaluated in patients with cerebral infarction. Results Compared with the control group, plasma t-pA activity in acute, subacute and convalescent phases of patients with cerebral infarction was significantly decreased, D-D content was significantly increased and recovered as the condition improved, and the greater the dynamic changes , The more the condition improved. Conclusions The decrease of plasma t-pA may be one of the causes of cerebral infarction. The increase of D-D is a sign of thrombolysis. Dynamic observation of the changes can be used as one of the indicators to judge the disease and prognosis.