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目的:探讨液固压缩技术使α-细辛脑快速溶出的机制。方法:以聚山梨酯-80为液体赋形剂,微晶纤维素PH-101为载体材料,微粉硅胶200为涂层材料,制备药液比1∶4的α-细辛脑液固压缩片,比较其与市售普通片的溶出度,通过测定X-射线衍射(XRD)和崩解时限,探讨该压缩片的速释机制。结果:液固压缩片中α-细辛脑在5 min时,溶出度>80%。XRD表明液固压缩片中无α-细辛脑的特征峰。结论:采用液固压缩技术可改善药物润湿性,增加药物溶出时有效表面积,使难溶性药物快速溶出。
OBJECTIVE: To investigate the mechanism of liquid-solid compression technology in rapidly dissolving α-asarone brain. Methods: Polysorbate-80 was used as the liquid excipient and microcrystalline cellulose PH-101 as the carrier material. Silica gel 200 was used as the coating material to prepare α-asarone fluid-solid compression ratio of 1: 4 The dissolution rate of tablets was compared with that of commercial tablets. The mechanism of immediate release of the tablets was discussed by measuring the XRD and disintegration time. Results: In the liquid-solid compressed tablets, the a-asarone brain dissolves more than 80% at 5 min. XRD showed that there was no characteristic peak of α- asarone in liquid-solid compressed tablets. Conclusion: The liquid-solid compression technology can improve the drug wettability, increase the effective surface area of drug dissolution, so that insoluble drugs quickly dissolve.