原发性干燥综合征是一种主要累及外分泌腺体的慢性炎症性自身免疫性疾病。由于本病起病多隐匿,临床表现多样,易误诊或漏诊。我科于2014年12月收治低钾血症患者1例后确诊为原发性干燥综合征致Ⅰ型肾小管酸中毒,同时伴桥本甲状腺炎,现报道如下。患者,女,53岁,因“反复肢体乏力3个月”入院。患者3个月前无明显诱因下出现全身乏力、肢体软瘫,就诊于当地医院,查血电解质示血钾1.60 Sjogren’s syndrome is a chronic inflammatory autoimmune disease that mainly affects exocrine glands. Due to the occult onset of this disease, clinical manifestations and diverse, easily misdiagnosed or missed diagnosis. Our department in December 2014 admitted to patients with hypokalemia in 1 case was diagnosed as primary Sjogren’s syndrome induced type I renal tubular acidosis, accompanied by Hashimoto’s thyroiditis, are reported below. Patient, female, 53 years old, due to “Repeated limb weakness 3 months ” admitted. Patients 3 months ago, there was no obvious incentive to cause generalized weakness, limb paralysis, visit a local hospital, check blood electrolytes showed potassium 1.60