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甲磺酸培氟沙星为喹诺酮类抗菌药,具有广谱抗菌作用,作用机理为抑制细菌DNA螺旋酶,用药时少数病例可出现不良反应:①胃肠道反应:如恶心、呕吐、食欲减退、腹泻等。②光敏反应、神经系统反应:如头晕、眩晕、头痛、震颤、失眠等。③皮疹,血清谷丙转氨酶上升,白细胞减低等。④偶见注射局部刺激症状。上术反应均属中轻度反应,停药后即可消失,然而甲磺酸培氟沙星致过敏性休克反应未见报道,我院曾遇到1例,现报告如下。1 病例报告 患者,女性,56岁。该患者因受凉,咳嗽、黄痰、流涕、发烧入院。入院后因病人既往青霉素过敏,遵医嘱处置给甲磺酸培氟沙星0.4g加10％葡萄糖250ml静点,半分钟后病人自觉穿刺部位麻木,随即出现恶心、呕吐、手足发凉、面色苍白、脉搏细数110次/分、呼吸困难、皮肤出现荨麻疹,血压9.0/60mmHg。病人既往有高血压(血压在160～200mmHg/90～
Pefloxacin mesylate quinolone antibacterial drugs, has a broad-spectrum antibacterial effect, the mechanism of action for the inhibition of bacterial DNA helicase, medication when a few adverse reactions can occur: ① gastrointestinal reactions: such as nausea, vomiting, loss of appetite , Diarrhea and so on. ② photosensitive reaction, nervous system reaction: such as dizziness, dizziness, headache, tremor, insomnia and so on. ③ rash, elevated serum alanine aminotransferase, leukopenia and so on. Occasionally injection of local irritation symptoms. On the surgical response are moderate reaction, after stopping can disappear, but the pefloxacin mesylate allergic shock response has not been reported, our hospital has encountered in 1 case, are as follows. 1 case report patient, female, 56 years old. The patient was cold, cough, yellow sputum, runny nose, fever admitted to hospital. After admission due to the patient’s previous penicillin allergy, prescribed by the doctor to give mesylate pefloxacin 0.4g plus 10% glucose 250ml static point, half a minute after the patient numbness of the puncture site, then nausea, vomiting, hand, foot and cold, pale , Pulse breakdown of 110 beats / min, difficulty breathing, skin urticaria, blood pressure 9.0 / 60mmHg. The patient had previous high blood pressure (blood pressure 160 ~ 200mmHg / 90 ~