本文探索了中西医结合治疗难治性肾病综合征的疗效，对３６例难治性肾病综合征患者应用云南灯盏花、激素与环磷酰胺联合治疗（治疗组）作了观察，并与３４例常规应用激素、环磷酰胺患者（对照组）比较，结果显示治疗组完全缓解率和总有效率分别为４７２％和８８９％，显著高于对照组的２９４％和５５９％（ｐ＜００５），而不良反应发生率治疗组为１９４％，显著低于对照组的４７１％（ｐ＜００５），表明中西医结合疗法是提高难治性肾病综合征疗效的有效途径。 This article explores the treatment of refractory nephrotic syndrome with integrated traditional Chinese and Western medicine, 36 cases of refractory nephrotic syndrome in Yunnan Erigeron, hormone and cyclophosphamide combined treatment (treatment group) was observed, and 34 cases Conventional application of hormones, cyclophosphamide patients (control group), the results showed that the treatment group complete remission rate and total effective rate was 47.2% and 88.9%, significantly higher than the control group 29.4% and 55% 9% (p <005), while the incidence of adverse reactions in the treatment group was 194%, which was significantly lower than 471% in the control group (p <005), indicating that the combination of traditional Chinese and Western medicine is to improve refractory Effective ways of treating nephrotic syndrome.