论文部分内容阅读
曾有文献证实酮康唑局部治疗对一些不仅仅是由真菌引起的皮肤病有效。一些基础药理研究表明酮康唑对角朊细胞内的胆固醇产生、对5-脂氧合酶以及对皮肤内全反式维甲酸的代谢有影响。由此产生一种假说,即局部应用酮康唑具有抗炎特性。作者进行动物试验以证实这种假说。于豚鼠背部去毛后24小时,在2×2 cm区域内划5个横向的划痕,再将活的或灭活的金黄色葡萄球菌接种于划痕区连续3天以引起红斑及角化过度等炎症反应。在最后一次接种后24小时开始局部应用0.5%或2%酮康唑软膏0.5g,每
It has been documented that topical treatment with ketoconazole is effective against some dermatological diseases not only caused by fungi. Some basic pharmacological studies have shown that ketoconazole on keratinocyte cholesterol production, 5-lipoxygenase and the skin all-trans retinoic acid metabolism. This led to the hypothesis that topical application of ketoconazole has anti-inflammatory properties. The authors conducted animal experiments to confirm this hypothesis. Twenty-four hours after the hair removal from the back of guinea pigs, five transverse scratches were drawn in a 2 × 2 cm area, and live or inactivated S. aureus were inoculated to the scratch area for three consecutive days to cause erythema and keratosis Excessive inflammatory response. Topically applied 0.5% or 2% ketoconazole ointment 0.5 g at 24 hours after the last inoculation, each