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目的观察噻托溴铵联合桉柠蒎肠溶软胶囊治疗慢性阻塞性肺疾病急性加重期(AECOPD)临床疗效。方法选择2012年7月-2014年9月医院收治的慢性阻塞性肺疾病急性加重期患者82例,随机分为试验组与对照组各41例。2组患者均予吸氧、解痉平喘、抗感染治疗。试验组加用噻托溴铵联合桉柠蒎肠溶软胶囊;对照组加用盐酸氨溴素口服液,以7d为1个疗程。1个疗程后比较2组临床疗效、平均住院天数及呼吸困难总改善率。结果试验组总有效率97.56%明显高于对照组的85.37%;试验组平均住院天数较对照组短,呼吸困难总改善率100.0%明显高于对照组的87.8%,差异均有统计学意义(P<0.05)。结论桉柠蒎联合噻托溴铵治疗慢性阻塞性肺疾病急性加重期疗效显著,安全可靠,值得临床推广使用。
Objective To observe the clinical efficacy of tiotropium combined with eucalyptus, tricalcium phosphate and softwood capsule in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Eighty-two patients with acute exacerbation of chronic obstructive pulmonary disease admitted from July 2012 to September 2014 in our hospital were randomly divided into experimental group and control group, 41 cases each. 2 patients were oxygen, spasm and asthma, anti-infective treatment. The experimental group plus tiotropium combined eucalyptus lemon pine enteric soft capsules; control group plus ammonia bromine oral solution to 7d for a course of treatment. After a course of treatment, the clinical efficacy, average days of hospitalization and total improvement of dyspnea in two groups were compared. Results The total effective rate of the experimental group was 97.56%, which was significantly higher than that of the control group (85.37%). The average length of stay in the experimental group was shorter than that of the control group. The total improvement rate of dyspnea was 100.0%, significantly higher than that of the control group (87.8% P <0.05). Conclusion Eucalyptus pinene combined with tiotropium for the treatment of chronic obstructive pulmonary disease in acute exacerbation of significant effect, safe and reliable, worthy of clinical promotion and use.