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目的研究三七皂甙对缺氧耐受力的影响。方法用3批小鼠分别以6.66、13.32、26.64mg/kg.BW3个剂量的三七皂甙(以纯的皂甙含量计)给小鼠灌胃,另设一个阴性对照组灌蒸馏水,连续30d后分别进行常压缺氧存活时间、亚硝酸盐中毒存活时间和急性脑缺血性缺氧存活时间测定。结果三七皂甙各剂量组小鼠常压缺氧存活时间、亚硝酸盐中毒存活时间及急性脑缺血缺氧存活时间的平均值均长于阴性对照组的平均值,其中高、中剂量组小鼠的亚硝酸盐中毒和急性脑缺血性缺氧存活时间与阴性对照组的差异具有显著性(P<0.01或P<0.05),表明受试样品能够延长小鼠急性脑缺血性缺氧及亚硝酸盐中毒后存活时间。结论三七皂甙对试验小鼠具有提高缺氧耐受力的功效。
Objective To study the effects of Panax notoginseng saponins on the tolerance to hypoxia. METHODS: Three batches of mice were given intragastrically with 3.66, 13.32, and 26.64 mg/kg.BW of three doses of panax notoginseng (based on pure saponin content), and a negative control group was given distilled water for 30 days. The normobaric hypoxic survival time, the nitrite poisoning survival time, and the acute cerebral ischemic hypoxia survival time were measured. RESULTS: Atmospheric hypoxia survival time, nitrite poisoning survival time, and acute cerebral ischemia/hypoxia survival time of mice in each dose group of Panax notoginseng were longer than the mean value of the negative control group. The high and medium dose groups were small. Rat nitrite poisoning and acute cerebral ischemic hypoxia survival time were significantly different from the negative control group (P<0.01 or P<0.05), indicating that the test sample could prolong the acute cerebral ischemic deficit in mice. Survival time after oxygen and nitrite poisoning. Conclusion Panax Notoginseng has the effect of improving hypoxic tolerance in experimental mice.