致畸试验阳性对照的选择

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一个完整的胚胎-胎仔发育毒性试验(Ⅱ段)实验剂量的设计包括阳性对照组和阴性对照组,设立对照组的目的在于屏蔽干扰因素,使其与试验组的非试验因素保持一致。只有设立了合适的对照,才能平衡非试验因素对试验结果的影响,从而把受试药物的效应充分显露出来,以观察药物带来的毒性效应,排除假 A complete embryo-fetal developmental toxicity test (Section II) The experimental dose design includes a positive control group and a negative control group. The purpose of establishing a control group is to mask the interference factor to be consistent with that of the test group. Only by setting up a proper control can we balance the impact of non-experimental factors on the test results so as to fully reveal the effects of the tested drugs to observe the toxic effects of the drugs and eliminate the false
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