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目的：观察黄芪注射液配合泼尼松治疗肾病综合征的疗效。方法：应用黄芪注射液配合泼尼松治疗肾病综合征４３例，并观察治疗前后血浆白蛋白水平、２４小时尿蛋白定量、尿纤维蛋白降解物（ＦＤＰ）、血尿素氮、血肌酐、总胆固醇、甘油三酯及血红细胞超氧化物歧化酶（ＲＢＣＳＯＤ）、还原型谷胱甘肽（ＧＳＨ）和丙二醛（ＭＤＡ）的变化。结果：４３例中治愈１８例，好转１５例，未愈１０例，总有效率为７６．７％。治疗后２４小时尿蛋白定量、尿ＦＤＰ、血尿素氮、血肌酐、总胆固醇、甘油三酯和ＭＤＡ均显著下降（Ｐ＜０．０５～０．０１），而血浆白蛋白、ＲＢＣＳＯＤ和ＧＳＨ均明显增高（Ｐ＜０．０５～０．０１）。结论：黄芪注射液配合泼尼松治疗肾病综合征，可改善肾功能，减少尿蛋白，提高血浆白蛋白水平，并有降低血脂及缓解肾小球高凝状态和抗氧自由基的作用。
Objective: To observe the curative effect of astragalus injection combined with prednisone on nephrotic syndrome. Methods: 43 patients with nephrotic syndrome were treated with astragalus injection combined with prednisone, and plasma albumin level, 24-hour urinary protein, FDP, BUN, serum creatinine, total cholesterol , Triglyceride and erythrocyte superoxide dismutase (RBCSOD), reduced glutathione (GSH) and malondialdehyde (MDA) were measured. Results: In 43 cases, 18 cases were cured, 15 cases improved, and 10 cases were unhealed. The total effective rate was 76.7%. Urinary protein, urinary FDP, blood urea nitrogen, serum creatinine, total cholesterol, triglyceride and MDA were significantly decreased 24 hours after treatment (P <0.05-0.01), while plasma albumin, RBCSOD and GSH Was significantly higher (P <0.05 ~ 0.01). Conclusion: Astragalus injection combined with prednisone in treatment of nephrotic syndrome can improve renal function, reduce urinary protein, increase plasma albumin level, reduce blood fat and relieve glomerular hypercoagulable state and antioxidant free radical.