目的对比米非司酮与桂枝茯苓加减丸联合用药或单独用药治疗子宫肌瘤的疗效。方法回顾性分析98例子宫肌瘤患者治疗方案及疗效。31例患者口服米非司酮片(米非司酮组);33例患者口服桂枝茯苓加减丸(桂枝茯苓丸加减丸组);34例患者同时服用两种药物(联合用药组),均连续用药3个月。检测子宫肌瘤体积以及血清卵泡刺激素(FSH)、黄体生成素(LH)、雌激素(E2)及孕酮(P)的浓度。结果联系用药3个月之后,3组患者月经量、经期时间、痛经以及腰部酸胀等症状较治疗前明显改善,其中联合用药组月经量较其他两组减少更为明显。米非司酮组、桂枝茯苓加减丸组、联合用药组治疗后子宫肌瘤体积较治疗前分别缩小了49.6%、44.1%以及71.2%,血清FSH、LH、E2、P的浓度较治疗前均明显降低(P<0.05),随访1年发现桂枝茯苓加减丸组及联合用药组无反弹。结论米非司酮与桂枝茯苓加减丸联合用药治疗子宫肌瘤疗效明显优于单独用药,值得临床推广应用。 Objective To compare the efficacy of mifepristone and Guizhi Fuling plus or minus pills in the treatment of uterine fibroids alone or in combination. Methods A retrospective analysis of 98 patients with uterine fibroids treatment and efficacy. Thirty-one patients were given mifepristone tablets (mifepristone group); 33 patients were given Guizhi Fuling Decoction (Guizhi Fuling Pill plus plus and minus pills group); 34 patients took both drugs (combination group) ), Were continuous medication for 3 months. Uterine fibroids volume, serum FSH, LH, E2 and progesterone (P) concentrations were measured. Results After 3 months of treatment, the symptoms of menstruation, menstrual period, dysmenorrhea and soreness in the waist were significantly improved after 3 months of treatment. The menstrual flow in the combination group was more obvious than the other two groups. The volume of uterine fibroids in the mifepristone group, Guizhi Fuling plus plus pill group and the combination group were 49.6%, 44.1% and 71.2% lower than those before treatment, respectively. The serum concentrations of FSH, LH, E2 and P were significantly lower than those before treatment (P <0.05). After one year of follow-up, there was no rebound in Guizhi Fuling plus and minus pills group and combination group. Conclusion The combination of mifepristone and Guizhi Fuling capsule treatment of uterine fibroids significantly better than the single drug, worthy of clinical application.