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目的 :观察增殖性肾炎 (PGN)肾组织中IL 8、CD11b生成与分布 ,探讨其意义。方法 :免疫组织化学方法检测 17例不同类型的PGN临床患者肾穿刺组织中IL 8、CD11b抗原蛋白 ,以 8例正常人肾组织及 7例膜性肾病 (MN)临床患者肾穿组织作对照检测。结果 :IL 8、CD11b在PGN肾组织大量检出 ,分布较广 ,检出率显著增高于正常对照组 (P <0 0 5、P <0 0 1)和MN对照组 (P <0 0 5、P <0 0 1)。结论 :PGN肾组织存在IL 8介导的有关炎症 ;IL 8、CD11b肾组织检测可予较好反映 ,IL 8及其炎症在PGN发病与病理中具促进作用。
OBJECTIVE: To observe the formation and distribution of IL 8 and CD11b in the proliferative glomerulonephritis (PGN) kidney and to explore its significance. Methods: Immunohistochemical method was used to detect IL8 and CD11b antigen in renal biopsies of 17 patients with different types of PGN. Kidneys were detected in 8 normal human renal tissues and 7 patients with membranous nephropathy (MN) . Results: IL 8 and CD11b were abundantly detected in the kidney of PGN, and the detection rate was significantly higher than that of the normal control group (P <0.05, P <0.01) and the MN control group (P <0.05 , P <0 0 1). CONCLUSION: IL-8-mediated inflammation is present in the kidney of PGN. The detection of IL-8 and CD11b in renal tissue can be well reflected. IL-8 and its inflammation play a role in the pathogenesis and pathology of PGN.