薄荷醇为一种环形乙醇,因其能产生凉爽感而被应用于食物、饮料、香烟和美容剂中。这种化合物可能通过阻断肠道平滑肌的Ca~(++)通道而减轻肠过敏综合症患者的腹胀和绞痛。最近报道薄荷醇雾化剂具有镇咳作用,而本文旨在探讨薄荷醇对气道高反应性哮喘病的作用。 研究对象为23名不吸烟的慢性轻度哮喘患者,男12例,女11例,年龄19～46岁,其中薄荷醇组有2例因出现不良反应而退出试验。所有病例在试验开始前4周内均无严重哮喘发作或呼吸道感染史,每例患者偶有哮喘症状,通过吸入常规剂量的β_2-肾上腺素能受体阻断剂即可缓解。研究中随机设计安慰剂对照组10例,薄荷醇组11例。 Menthol, a type of circular ethanol, is used in foods, beverages, cigarettes and cosmetics for its coolness. This compound may reduce bloating and colic in patients with irritable bowel syndrome by blocking the Ca ~ (++) channel of intestinal smooth muscle. The recent reports that menthol nebulizer has antitussive effects, and this article aims to investigate the role of menthol in airway hyperresponsiveness asthma. Twenty-three non-smokers with chronic mild asthma were enrolled in this study, including 12 males and 11 females, aged 19 to 46 years, of whom 2 were excluded from the trial due to adverse reactions. All cases had no history of severe asthma attacks or respiratory infections within 4 weeks prior to the start of the trial. Each patient occasionally had asthma symptoms and was relieved by inhalation of a conventional dose of β 2 -adrenoceptor blocker. Ten patients in the placebo group and 11 in the menthol group were randomized in the study.