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伯喹在疟疾根治中具重要作用,其与氯喹合用是沙巴地区根治疟疾的常规药物。但伯喹对红细胞G-6-PD缺乏的患者易引起溶血反应。作者观察了伯喹引起溶血的程度,并探讨周效磺胺乙胺嘧啶合剂(法西达)治疗G-6-PD缺乏的疟疾患者的疗效。沙巴地区2年内陆续住院的1103例疟疾患者,入院后用Brewer氏正铁血红蛋白减少试验测定红细胞G-6-PD,有109例(9.8%)G-6-PD缺乏,其中40例因各种原因未列入本试验,其余69例患者中男性36例,女性33例;成人47例,儿童22例;G-6-PD完全缺乏者45例(男36,女9),部份缺乏者24例(全部女性)。随机分3组进行治疗:第1组单用氯
Benroqin plays an important role in the cure of malaria and its combination with chloroquine is a routine drug for the cure of malaria in Sabah. However, primaquine predisposes to hemolysis in patients with G-6-PD deficient erythrocytes. The authors looked at the extent of primaquine-induced hemolysis and investigated the efficacy of the potent sulfamethoxazole (faxacid) combination in the treatment of G-6-PD-deficient malaria patients. A total of 1103 malaria patients were hospitalized in Sabah in 2 years. 109 patients (9.8%) had G-6-PD deficiency after being admitted to the hospital for determination of erythrocyte G-6-PD with the Brewer’s methemoglobin reduction test. The reasons were not included in this study, the remaining 69 patients, 36 males and 33 females; 47 adults and 22 children; 45 cases of complete lack of G-6-PD (male 36, female 9), some were 24 cases (all women). Randomly divided into three groups for treatment: the first group with chlorine alone