近年来,EGF,TGF-α和-β、PDGF等生长因子及其受体及有关癌基因方面的研究进展,深化了雌素促癌作用机理的研究。某些妇科肿瘤的发生发展可能由雌素通过其受体,改变正常生长因子的自分泌或旁分泌调控,和/成有关癌基因异常表达所致。测定某些生长因子受体状况和癌基因表达程度,可改善妇科肿瘤病人的预后判断。有关研究还有助于探寻新的抗癌治疗途径。 In recent years, EGF, TGF-α and-β, PDGF and other growth factors and their receptors and related oncogene research advances, deepen the estrogen promote cancer research. The development of certain gynecologic tumors may be caused by estrogen through its receptor, to change the autocrine or paracrine regulation of normal growth factors, and / or related to the abnormal expression of oncogenes. Determining the status of certain growth factor receptors and the degree of oncogene expression may improve the prognosis of gynecologic oncology patients. The study also helps to find new ways to fight cancer.