三种密切相关的Ras蛋白,即Kras、Hras和Nras构成了小分子GTP酶的Ras超家族成员,它们可以作为分子开关,传递细胞外信号从而引发一系列基本的细胞过程,包括增殖、存活和分化[1,2]。癌症生物学家发现在人类肿瘤细胞中,编码这些蛋白的基因突变率较高[2,3]。大约30%的人类肿瘤细胞中出现Ras基因突变,也有一系 Three closely related Ras proteins, Kras, Hras, ​​and Nras, are members of the Ras superfamily of small molecule GTPases that act as molecular switches that transmit extracellular signals that trigger a series of basic cellular processes including proliferation, survival and Differentiation [1,2]. Cancer biologists have found that there is a high rate of mutation in genes that encode these proteins in human tumor cells [2,3]. About 30% of human tumor cells appear Ras gene mutation, but also a series