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目的探讨白术挥发油对小鼠H22肝癌淋巴道转移的抑制作用及相关机理。方法ELISA法检测小鼠H22肝癌淋巴道转移模型血清中MMP-9的表达。结果白术挥发油各剂量组对小鼠H22肝癌淋巴道转移模型的肺转移率有明显抑制作用;白术挥发油能显著降低H22肝癌淋巴道转移模型小鼠血清中MMP-9的含量。结论白术挥发油可能通过抑制MMP-9的分泌起到抗肿瘤侵袭转移的作用。
Objective To investigate the inhibitory effect of volatile oil from Atractylodes macrocephala on lymph node metastasis of H22 hepatocarcinoma in mice and its related mechanism. Methods ELISA was used to detect the expression of MMP-9 in serum of H22 hepatoma lymphatic metastasis model. Results The volatile fractions of Atractylodes macrocephala Koidz oil could inhibit the lung metastasis rate of H22 hepatocarcinoma lymphatic metastasis model. Atractylodes volatile oil could significantly reduce the content of MMP-9 in the serum of H22 hepatocellular carcinoma lymphatic metastasis model mice. Conclusion Atractylodes macrocephala oil may play a role in anti-tumor invasion and metastasis by inhibiting the secretion of MMP-9.