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有机磷农药是农、林、卫生等方面广泛应用的高效杀虫剂,少数品种还可作为杀菌剂。其中毒作用机理主要是抑制体内胆碱酯酶的活性。现就有机磷农药中毒有关的一些生化向题作一介绍,将有助于临床正确诊断和治疗。一、有机磷农药的毒性和代谢有机磷农药毒性大小与其化学结构密切有关。常(?)用有机磷农药的基本化学结构通式为式中R和R′可为烷基或羟胺基;X是烷氧基或芳氧基或卤基等;Y为硫或氧。一般地说,R基团为乙基较甲基的毒性大(乙基1605毒性较甲基1605大2.5
Organophosphorus pesticides are highly effective insecticides widely used in agriculture, forestry and public health, and a few species can also be used as fungicides. Its toxic mechanism of action is mainly to inhibit the activity of cholinesterase in vivo. Now on the organophosphorus pesticide poisoning related to some of the biochemical to make an introduction, will help clinical correct diagnosis and treatment. First, the toxicity and metabolism of organophosphorus pesticides Organophosphorus pesticide toxicity and its chemical structure is closely related. The general chemical structure of the organophosphorus pesticide used in the conventional (?) General formula is: wherein R and R ’are alkyl or hydroxyamino; X is alkoxy or aryloxy or halo; and Y is sulfur or oxygen. In general, the R group is more toxic to ethyl than methyl (ethyl 1605 is 2.5 more toxic than methyl 1605