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A group of 3-amino-2-pyrones were synthesized and their biological activities were evaluated for inhibiting cyclooxygenase(COX) activity.This study has led to the identification of COX-1-selective inhibitors.Among the tested compounds,the compound 5j exhibited the most potent COX-1 inhibitory activity(IC_(50) = 19.32μg/mL) and COX-1 selectivity index(SI = 41.98).
A group of 3-amino-2-pyrones were synthesized and their biological activities were evaluated for inhibiting cyclooxygenase (COX) activity. This study has led to the identification of COX-1-selective inhibitors. the most potent COX-1 inhibitory activity (IC 50 = 19.32 μg / mL) and COX-1 selectivity index (SI = 41.98).