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目的 研究新生儿缺氧缺血血性脑病 (HIE)患儿血白细胞介素 10 (IL 10 )水平变化 ,探讨IL 10水平与HIE之间的关系。方法 采用ELISA法测定新生儿血清IL 10水平 ,HIE组 2 0例和对照组 2 0例。标本取自本院 ,分 3组 ,HIE治疗前组、治疗后组和对照组。结果 HIE治疗前组IL 10水平中位数为 3 16pg/ml;明显高于对照组的 15 3pg ml和治疗后组的 12 3 5 9g ml;对照和治疗后组间差异无显著性。结论 新生儿HIE血清IL 10水平变化与HIE有关 ,IL 10在新生儿缺氧缺血性脑病的发病机理中起重要作用。
Objective To investigate the level of interleukin 10 (IL 10) in neonates with hypoxic-ischemic encephalopathy (HIE) and to explore the relationship between IL-10 and HIE. Methods Serum levels of IL-10 were measured by ELISA in 20 neonates with HIE and 20 controls. Specimens taken from our hospital, divided into 3 groups, HIE before treatment group, after treatment group and control group. Results The median level of IL-10 before HIE treatment was 3 16 pg / ml, significantly higher than 15 3 pg ml in the control group and 12 3 5 9 g ml in the treated group. There was no significant difference between the control group and the post-treatment group. Conclusion The change of IL 10 level in neonates with HIE is related to HIE. IL 10 plays an important role in the pathogenesis of neonatal hypoxic-ischemic encephalopathy.