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目的观察米非司酮治疗子宫内膜异位症的临床疗效。方法子宫内膜异位症患者90例随机分为3组,各30例,A,B组均于月经周期第1天开始口服米非司酮治疗,剂量分别为12.50,6.25mg/d,连续用药6个月;C组采用常用药物(如孕三烯酮片)治疗。结果 A,B组疗效、血清激素水平与C组比较差异均有统计学意义(P<0.05);A组不良反应发生率高于B组(P<0.05)。结论米非司酮治疗子宫内膜异位症疗效优于常用药物,但大剂量应用不良反应多,建议先选用小剂量米非司酮治疗。
Objective To observe the clinical efficacy of mifepristone in the treatment of endometriosis. Methods Ninety patients with endometriosis were randomly divided into three groups, 30 cases in each. Groups A and B were started oral mifepristone on the first day of the menstrual cycle, the doses were 12.50 and 6.25 mg / d, respectively, Medication for 6 months; C group using commonly used drugs (such as gestodeoenone tablets) treatment. Results The curative effect of group A and B and the level of serum hormone were significantly different from those of group C (P <0.05). The incidence of adverse reactions in group A was higher than that of group B (P <0.05). Conclusion The efficacy of mifepristone in the treatment of endometriosis is superior to the commonly used drugs, but the adverse effects of large doses of application, it is recommended to use low-dose mifepristone treatment.