1964年,劳森(Lawson)等于实验动物发现十二指肠液进入胃内可以引起浅表性萎缩性胃炎和上皮增生。单纯胰液对胃粘膜作用较弱,如胆汁和胰液一起进入胃内则作用较强,并以胃窦部损害较重。若用 Roux-en-y胃空肠吻合术,使胆汁不进入胃内,结果病变均有好转。1970年柯克(Kirk)等将实验动物的胆囊或胆道与胃窦吻合,发现动物发生胃炎、胃粘膜糜烂或溃疡。临床上通过内窥镜观察,发现胃炎及溃疡病患者胃内常有胆 In 1964, Lawson was equal to the experimental animals found duodenal fluid into the stomach can cause superficial atrophic gastritis and epithelial hyperplasia. Simple pancreatic juice on the role of the gastric mucosa is weaker, such as bile and pancreatic juice together into the stomach, the role of strong, and damage to the gastric antrum heavier. If Roux-en-y gastrojejunostomy, so that bile does not enter the stomach, the results were improved lesions. In 1970, Kirk et al fitted the gallbladder or biliary tract of the experimental animal with the antrum and found that the animal had gastritis, gastric mucosal erosions or ulcers. Clinically observed by endoscopy, gastritis and ulcer patients found in the stomach often gall