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目的探讨DcR3基因和血管内皮生长因子(VEGF)在结直肠癌组织中的表达及意义。方法对61例结直肠癌组织和10例正常结直肠组织(对照组)采用免疫组化方法进行DcR3和VEGF的检测。结果 61例结直肠癌中37例DcR3(+);48例VEGF(+)。正常肠组织(-),两者的阳性表达与淋巴结转移、DUCK分期有关。结论DcR3和VEGF二者联合检测可以为临床诊治结直肠癌提供理论依据。
Objective To investigate the expression and significance of DcR3 gene and vascular endothelial growth factor (VEGF) in colorectal cancer. Methods 61 cases of colorectal cancer tissues and 10 cases of normal colorectal tissues (control group) were examined by immunohistochemistry for DcR3 and VEGF. Results 61 cases of colorectal cancer in 37 cases of DcR3 (+); 48 cases of VEGF (+). Normal intestinal tissue (-), the positive expression of both and lymph node metastasis, DUCK staging. Conclusion The combined detection of DcR3 and VEGF can provide a theoretical basis for clinical diagnosis and treatment of colorectal cancer.