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目的探讨美罗培南在治疗机械通气新生儿下呼吸道细菌感染中的疗效。方法对应用机械通气的新生儿下呼吸道细菌感染患儿37例采用美罗培南静脉注射治疗,美洛培南治疗方法和剂量为20~30mg/kg,每日2次,静脉滴注。临床疗效评价分为痊愈、显效、进步和无效。痊愈和显效作为有效统计。结果除1例嗜麦芽窄食单胞菌对美罗培南耐药外,其余22例革兰阴性细菌均为敏感,达95·7%。在治疗结束时,痊愈19例,显效7例,进步2例,无效9例。总有效率为70·3%。无不良反应发生。结论美罗培南适用于机械通气的新生儿下呼吸道细菌感染,值得临床进一步研究。
Objective To investigate the efficacy of Meropenem in the treatment of bacterial infections of lower respiratory tract in neonates with mechanical ventilation. Methods 37 cases of children with bacterial infection of neonatal lower respiratory tract with mechanical ventilation were treated with Meropenem intravenous injection, meropenem treatment method and the dose of 20 ~ 30mg / kg, 2 times a day, intravenous drip. Clinical efficacy evaluation is divided into cured, markedly effective, progressive and ineffective. Healed and marked as effective statistics. Results In addition to 1 case of Stenotrophomonas maltophilia resistant to meropenem, the remaining 22 cases of gram-negative bacteria were sensitive, reaching 95.7%. At the end of the treatment, 19 cases were cured, 7 cases markedly improved, 2 cases improved and 9 cases ineffective. The total effective rate was 70.3%. No adverse reactions occurred. Conclusion Meropenem is suitable for bacterial infection of lower respiratory tract in neonates with mechanical ventilation, which is worth further clinical study.