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目的探讨血清降钙素原(PCT)在早期诊断新生儿严重细菌感染性疾病中的临床意义。方法将我科2012年4月至8月收治的86例新生儿感染患者与同期31例非感染新生儿,分为重症感染、局部感染与非感染组,进行血清PCT测定,并与C反应蛋白(CRP)进行比较。结果以PCT≥0.5ng/ml为阳性,重症感染组PCT阳性率显著高于局部感染组和非感染组(91.84%vs37.84%和16.13%,P均<0.05);重症感染组CRP阳性率均高于与B、C组(73.47%vs29.73%和41.94%,P均<0.01)。PCT敏感性、阳性预测值、阴性预测值、约登指数高于CRP。结论 PCT可作为新生儿重症细菌感染早期诊断的标志物,并能提示感染的严重程度及预后。
Objective To investigate the clinical significance of serum procalcitonin (PCT) in the early diagnosis of severe bacterial infections in neonates. Methods 86 cases of neonatal infection and 31 cases of non-infected newborns admitted to our department from April to August in 2012 were divided into severe infection, local infection and non-infection group. Serum PCT was measured and compared with C-reactive protein (CRP) for comparison. The positive rate of PCT was 0.5ng / ml in PCT group, and the positive rate of PCT in severe infection group was significantly higher than that in local infection group and non-infected group (91.84% vs37.84% and16.13%, P <0.05). The positive rate of CRP in severe infection group Were higher than those in group B and C (73.47% vs29.73% and 41.94%, P <0.01 respectively). PCT sensitivity, positive predictive value, negative predictive value, Youden index higher than CRP. Conclusion PCT can be used as a marker of early diagnosis of severe bacterial infection in newborn and can indicate the severity and prognosis of infection.