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核酸代谢异常及蛋白合成减少是Alzheimer氏病(AD)的特征.作者为了研究AD时纤维性星形细胞的核酸改变,对10例尸检证实的AD患者(年龄51～88岁)和10例年龄相匹配的无痴呆患者作为对照,测定其海马终板和齿回分子层的胶质纤维酸性蛋白(glial fibrillary acidic protein, GFAP)阳性细胞和终板的锥体神经元的RNA含量,并进行了对照研究.结果:(1)在AD与对照组之间GFAP的星形细胞形态学特征无差异;(2)两组齿回分子层的星形细胞的RNA含量与海马终板星形细胞的RNA含量无差异.而终板的锥体神经元的RNA在AD患者比对
In order to study the nucleic acid changes of fibrotic astrocytes in AD, 10 patients with AD confirmed by autopsy (aged 51-88 years) and 10 patients with age The matched patients without dementia served as controls and the RNA content of pyramidal neurons in glial fibrillary acidic protein (GFAP) positive cells and endplates in the hippocampal endplate and dentate gyrus was measured and compared (1) The morphological characteristics of astrocytes in GFAP were not different between AD group and control group; (2) The RNA content of astrocytes in the dentate gyrus in both groups was significantly higher than that in hippocampal end-plate astrocytes There was no difference in RNA content, whereas endplate pyramidal neuronal RNA was aligned in AD patients