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目的观察血浆灌流治疗重型肝炎伴银屑病及服用治疗银屑病药物导致严重肝损伤的治疗效果,总结经验。方法河南省传染病医院肝病科2009年10月~2010年8月3例重型肝炎伴银屑病患者,均为男性,年龄36~48岁,平均年龄43.9岁;其中1例服用自制治疗银屑病药物导致严重肝损伤。对其进行血浆灌流治疗,治疗期间未用任何治疗银屑病药物,在常规护肝药物治疗基础上,予以HB-H-6树脂吸附胆红素血浆灌流3~4次,每次间隔2~4 d,治疗前及每次治疗结束后评估患者皮损及肝功能情况并进行对比。结果 3例患者经3~4次血浆灌流治疗,银屑病症状明显改善,肝功能明显好转。结论血浆灌流不仅能治疗重型肝炎,对银屑病也有很好的治疗效果,可能成为银屑病新的治疗手段。
Objective To observe the therapeutic effect of plasma perfusion in the treatment of severe hepatitis with psoriasis and taking psoriasis drugs to cause severe liver injury and to summarize the experience. Methods Henan Provincial Infectious Diseases Hospital of Liver Diseases from October 2009 to August 2010 3 cases of severe hepatitis patients with psoriasis, were male, aged 36 to 48 years, mean age 43.9 years; of which 1 case of taking homemade treatment of psoriasis Sickness causes severe liver damage. The patients were treated with plasma perfusion, without any treatment of psoriasis drugs during the treatment period, on the basis of conventional liver protection drug therapy, HB-H-6 resin was adsorbed bilirubin plasma perfusion 3 to 4 times, each interval of 2 ~ 4 d, before treatment and after each treatment to assess the patient’s lesions and liver function and comparison. Results Three patients were treated with plasma perfusion 3 ~ 4 times, the symptoms of psoriasis were improved obviously, and the liver function improved obviously. Conclusion Plasma perfusion not only treats severe hepatitis but also has good therapeutic effect on psoriasis and may be a new treatment for psoriasis.