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目的探求内皮素（Endothelin，ET）及降钙素基因相关肽（calcitoniningene-relatedpeptide，CGRP）在新生儿缺氧缺血性脑病（HIE）时的变化。方法用放免法动态监测了18例HIE儿出生dl、d5血浆ET、CGRP的浓度，并与18例对照组比较。结果HIE组血浆ET、CGRP水平出生dl比对照组显著升高，经治疗5d后较前显著下降，治疗前后ET与CGRP呈正相关性。结论HIE时因缺氧缺血ET产生释放增多，CGRP因对ET有拮抗作用，在HIE时的升高可能是一种代偿机制。
Objective To investigate the changes of endothelin (ET) and calcitonin gene-related peptide (CGRP) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods The plasma concentrations of ET and CGRP in plasma of dl and d5 in 18 HIE children were dynamically monitored by radioimmunoassay and compared with 18 control subjects. Results The plasma levels of ET and CGRP in the plasma of HIE group were significantly higher than those of the control group. The levels of plasma ET and CGRP in the HIE group were significantly lower than those of the control group 5 d after the treatment. ET and CGRP were positively correlated before and after treatment. Conclusions The release of endothelin (ET) due to hypoxia-ischemia in HIE is increased, and CGRP is antagonistic to ET. The increase in HIE may be a compensatory mechanism.