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作者报导4例年青男子因溃疡性结肠炎服用磺胺息拉净(Sulphasalazine)造成精子减少而引起不育。例1,25岁,便血1年,诊断为溃疡性结肠炎,每天用磺胺息拉净3～4克,持续6年。后因不育就诊,检查发现其精子不正常,但其睾丸及内分泌水平均正常,无抗精子抗体。考虑患者不育的原因可能系服用磺胺息拉净所致,乃停药。不久精子计数特别在活动力方面显示改善。后其妻妊娠。5个月后因再服用磺胺息拉净,精子数及活动力又见减退。
The authors report that 4 young men developed infertility due to sperm depletion caused by ulcerative colitis taking Sulphasalazine. Cases 1,25 years old, blood in the stool for 1 year, diagnosed with ulcerative colitis, daily net absorption of sulfa 3 to 4 grams for 6 years. After infertility treatment, check the sperm is not normal, but the testis and endocrine levels are normal, no anti-sperm antibodies. Consider the reasons for infertility may be due to take sulfonylurea net result, is withdrawal. Soon the sperm count showed improvement especially in terms of mobility. After his wife’s pregnancy. After 5 months due to re-taking sulfonylurea net, sperm count and activity decreased again.