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基质金属蛋白酶（ＭＭＰｓ）是一组锌依赖蛋白酶，它主要参与细胞外基质（ＥＣＭ）的降解、转运、组织重塑［１］。ＭＭＰ－９是ＭＭＰｓ家族中最大的成员，主要降解ＩＶ型胶原，在一定的病理条件下，对细胞的迁移、侵袭、活化及动脉硬化的形成、血管重塑等均起重要作用［２］?
Matrix metalloproteinases (MMPs) are a group of zinc-dependent proteases that are mainly involved in the degradation, transport and remodeling of extracellular matrix (ECM) [1]. MMP-9, the largest member of the MMPs family, mainly degrades type IV collagen and plays an important role in cell migration, invasion, activation and atherosclerosis formation and vascular remodeling under certain pathological conditions [2].