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谷胱苷肽转移酶(GST)是以谷胱苷肽为共同底物的一组具有解毒功能的同工酶。国外研究证明血吸虫的GSTs含量丰富,是研究日本血吸虫疫苗的主要侯选抗原之一。有关日本血吸虫大陆株GST抗原的研究,作者曾在日本血吸虫24—26kDa和90kDa蛋白质“靶抗原”的抗原性研究,应用24—26kDa和90kDa蛋白质“靶抗原”免疫小鼠研制抗血吸虫“靶抗原”单克隆抗体,24—26kDa和90kDa蛋白质抗原用于血吸虫病诊断的可能性探讨,日本血吸虫24—26kDa抗原和重组Sj26抗原的抗原性和免疫原性比较研究等论文以及有关血吸虫疫苗研制的综
Glutathione transferase (GST) is a group of detoxification isoenzymes that use glutathione as a common substrate. Foreign studies have shown that the GSTs rich in Schistosoma japonicum vaccine is one of the major candidate antigens. For the study of GST antigen of Schistosoma japonicum mainland strain, the authors studied the antigenicity of 24-26 kDa and 90 kDa protein “target antigen” of Schistosoma japonicum and developed anti-schistosome “target antigen by immunizing mice with 24-26 kDa and 90 kDa protein” target antigen “ ”Monoclonal Antibodies, 24-26kDa, and 90kDa Protein Antigens for the Diagnosis of Schistosomiasis, A Comparative Study of the Antigenicity and Immunogenicity of the 24-26kDa Antigen of Schistosoma japonicum and the Recombinant Sj26 Antigen, and the Synthesis of Schistosoma vaccine Vaccine Development