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目的 观察高功率密度毫米波照射对大鼠免疫功能的影响。方法 用二乙基亚硝胺 (DEN)喂养大鼠致肝肿瘤模型 ,以频率 2 5 .8GHz ,功率 10 0mW /cm2 的毫米波直接照射肝区和循经照射肝俞 ,每次2 0min ,每周 2次 ,连续进行 5周和 10周 ,检测大鼠碱性磷酸酶 (AKP)、γ 谷氨酰转肽酶 (γ GT)、、胆汁酸(BA)和脾淋巴细胞转化指数 (LTIS)。结果 与肿瘤对照组相比 ,毫米波直接和循经照射 10周组大鼠LTIS提高 (1.76± 0 .3 8,2 .2 7± 0 .63vs 1.0 1± 0 .0 8,P <0 .0 5 ) ,照射 5周各组转化指数提高 ,但无统计学意义 (1.48± 0 .3 0 ,1.43± 0 .2 5vs 1.0 1± 0 .0 8,P >0 .0 5 )。AKP、γ GT、BA与正常对照组相比升高 (P <0 .0 5 ) ,而与肿瘤对照组相比有下降趋势 (P >0 .0 5 )。结论 高功率密度毫米波照射可提高大鼠的免疫功能和抑制DEN对肝脏的毒性作用
Objective To observe the effect of high power density millimeter wave irradiation on immune function in rats. METHODS: The rat hepatic neoplasms model was fed with diethylnitrosamine (DEN). The frequency of 25.8 GHz and the power of 100 mW/cm2 were directly irradiated to the liver area and the irradiated livers were irradiated for 20 min each time. Two weeks a week for 5 weeks and 10 weeks, rats were tested for alkaline phosphatase (AKP), gamma glutamyl transpeptidase (γ GT), bile acid (BA), and spleen lymphocyte transformation index (LTIS). ). Results Compared with the tumor control group, the LTIS was increased in the millimeter wave group and in the group exposed to irradiation for 10 weeks (1.76 ± 0.38, 2.27 ± 0.63 vs 1.01 ± 0.08, P <0. 0 5), the conversion index of each group increased after 5 weeks of irradiation, but there was no statistical significance (1.48±0.30, 1.43±0.25vs 1.0 1±0.08, P>0.05). AKP, γ GT, and BA increased compared with the normal control group (P <0.05), but decreased compared with the tumor control group (P > 0.05). Conclusion High power density millimeter wave irradiation can improve the immune function of rats and inhibit the toxic effect of DEN on the liver