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目的探讨血清cTNI、MYO、CK-MB、NT-proBNP水平与一氧化碳中毒患者心肌损伤的相关性。方法选择50例一氧化碳中毒患者为研究对象,分为轻度中毒组和重度中毒组,同时选取50例同期来体检健康者为健康组,分别检测并比较3组研究对象血清cTNI、MYO、CK-MB、NT-proBNP水平。对所有患者均采用磷酸肌酸钠治疗,比较治疗前后2组血清cTNI、MYO、CK-MB、NT-proBNP水平变化,探讨血清cTNI、MYO、CK-MB、NT-proBNP水平与一氧化碳中毒后心肌损伤的相关性。结果重度中毒组血清cTNI、MYO、CK-MB、NT-proBNP水平明显高于轻度中毒组和健康组(P均<0.05),轻度中毒组血清cTNI、MYO、CK-MB、NT-proBNP水平明显高于健康组(P均<0.05);治疗后轻、重度中毒组血清cTNI、MYO、CK-MB、NT-proBNP水平显著低于治疗前(P<0.05)。结论血清cTNI、MYO、CK-MB、NT-proBNP水平与一氧化碳中毒患者心肌损伤程度密切相关,可作为评估一氧化碳中毒后心肌损伤程度和治疗效果的临床诊断指标。
Objective To investigate the correlation between serum levels of cTNI, MYO, CK-MB and NT-proBNP and myocardial damage in patients with carbon monoxide poisoning. Methods Fifty patients with carbon monoxide poisoning were selected as study subjects. They were divided into mild poisoning group and severe poisoning group. Meanwhile, 50 healthy people were selected as healthy group in the same period. The levels of cTNI, MYO and CK- MB, NT-proBNP levels. The levels of cTNI, MYO, CK-MB and NT-proBNP were compared between the two groups before and after treatment. The levels of serum cTNI, MYO, CK-MB and NT-proBNP in serum of patients with carbon monoxide poisoning Correlation of injury. Results Serum levels of cTNI, MYO, CK-MB and NT-proBNP in severe poisoning group were significantly higher than those in mild poisoning group and healthy group (all P <0.05). Serum cTNI, MYO, CK- (P <0.05). After treatment, the levels of cTNI, MYO, CK-MB and NT-proBNP in patients with mild and severe poisoning were significantly lower than those before treatment (P <0.05). Conclusions The levels of cTNI, MYO, CK-MB and NT-proBNP in serum are closely related to the degree of myocardial injury in patients with carbon monoxide poisoning, which can be used as a clinical diagnostic index to evaluate the degree of myocardial injury and the therapeutic effect after carbon monoxide poisoning.