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对于原发性慢性肾上腺皮质功能减退症(Addison氏病)和肾上腺切除术后继发性肾上腺功能不全(Nelson氏病)的治疗,普遍采用皮质醇激素替代疗法,但其缺点是须终生服药,用药量不容易掌握,而且单一的糖皮质激素短缺问题。因此,同种异体肾上腺移植治疗Addison氏病和Nelson氏病的研究及临床应用逐渐开展起来,本文就其发展和近况作一简要综述。一、发展概况同种异体肾上腺移植的发展受人工合成糖皮质激素的影响很大。陈忠华等将其发展分为3个阶段:1.糖皮质激素人工合成以前的组织块移植阶段,即本世纪20～40年代,此期共做埋藏式肾上腺组织块
Cortisol replacement therapy is commonly used for the treatment of primary chronic adrenal hypofunction (Addison’s disease) and secondary adrenal insufficiency after adrenalectomy (Nelson’s disease), but has the disadvantage of requiring lifelong medication, Medication is not easy to grasp, but a single shortage of glucocorticoid. Therefore, allogeneic adrenalectomy treatment of Addison’s disease and Nelson’s disease research and clinical applications gradually started, this article on its development and recent status for a brief review. First, the development of Allogeneic adrenal transplantation is greatly affected by the synthetic glucocorticoid. Chen Zhonghua will be divided into three stages of its development: 1. Glucocorticoid synthesis of the previous block transplant stage, that is, 20 to 40 years of this century, this period a total of buried adrenal tissue block