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一、甲型肝炎病毒(HAV) 1973年,Feinstone首先报告用免疫电镜在甲肝者粪便中找到甲肝病毒颗粒,直径23～31nm,平均为27nm。1977年以前称之为CR326毒株。1979年Provost报告用CR326毒株感染狨猴成功;并能在狨猴肝细胞内繁殖,也可在恒河猴肾细胞内传代。近年来,美国和西德在猴胎肝细胞与Hela细胞分离得HAV。国内1980年用CR326毒株感染红面猴,1982年以HAV接种于Hela细胞,1983年将CR326毒株接种于肺组织均获成功。
First, Hepatitis A virus (HAV) In 1973, Feinstone first reported the use of immunoelectron microscopy in hepatitis A stool found in hepatitis A virus particles, diameter 23 ~ 31nm, with an average of 27nm. Before 1977, it was called CR326 strain. In 1979, Provost reported that CR326 strain was infected with marmoset successfully; it could propagate in marmoset liver cells and also in rhesus monkey kidney cells. In recent years, the United States and West Germany have isolated HAV from monkey hepatocytes and Hela cells. In China, the CR326 strain was infected with the red monkey in 1980, HAV was inoculated into Hela cells in 1982, and the CR326 strain was inoculated into the lung tissue successfully in 1983.